|Calculated MW||134326 Da|
|Positive Control||3T3 cell lysate|
|Application & Usage||Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti- Jagged 1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Jagged 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor- induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor- induced angiogenesis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in a variety of tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Jagged belongs to the DeltaSerrateLag2 (DSL) family of ligands that activate LIN12/Notch proteins. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged 1is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Mutation in Jagged1 is associated with an autosomal dominant disorder known as Alagille syndrome and Familial Tetralogy of Fallot a form of complex congenital heart disease.
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