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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Phospho-IRS (Ser616) Antibody (Clone HIR-B1)   

Phospho-IRS (Ser616) Antibody (Clone HIR-B1)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35568
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names HIR-B1
Calculated MW 131591 Da
Additional Information
Gene ID 3667
Application & Usage The antibody can be used for indirect ELISA and WB.
Other Names IRS, phospho-IRS, Phospho-IRS (Ser616)
Target/Specificity Phospho-IRS
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (1.0 mg/ml) purified mouse monoclonal antibody supplied in PBS with 0.05% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPhospho-IRS (Ser616) Antibody (Clone HIR-B1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRS1
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Research Areas
Citations (0)

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Insulin receptor substrates (IRS) subtypes are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm’s tumors, and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.

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$ 285.00
Cat# ABV10082
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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