|Application ||IF, E|
|Calculated MW||11121 Da|
|Positive Control||Rat Colon Tissue|
|Application & Usage||The antibody can be used for indirect ELISA for detection of antigen (recommended use at 1-2 µg/ml) and Immunofluorescence (recommended use at 20-40 µg/ml).|
|Other Names||PYY3-36, Peptide YY|
|Formulation||100 µg (0.5 mg/ml) affinity purified mouse monoclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||PYY3-36 Antibody (Clone RPY-B12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.|
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Provided below are standard protocols that you may find useful for product applications.
Peptide YY (PYY), a member of a neuropeptide Y (NPY family) is a 36 AA peptide secreted from the L cells of the gastrointestinal tract in response to food intake. The release of PYY is stimulated by nutrients within the lower small intestine and the colon, which in turn decreases food intake by inhibiting gut motility. It acts as an “ileal brake” to cause a sense of satiety. PYY3-36 is produced by the dipeptidyl peptidase-IV digestion of polypeptide YY (PYY).
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