|Application ||WB, E|
|Calculated MW||52785 Da|
|Application & Usage||The antibody can be used for ELISA (0.25 µg/ml) and Western blotting (2.5 – 5.0 µg/ml).|
|Other Names||Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Transcription factor HNF-4, Nuclear receptor subfamily 2 group A membre 1, Transcription factor 14, HNF4A, HNF4, NR2A1, TCF14|
|Formulation||100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||HNF4A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HNF4, NR2A1, TCF14|
|Function||Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in this protein have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.
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