Hrk Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O00198 |
Other Accession | AAC34931 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 9884 Da |
Gene ID | 8739 |
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Application & Usage | Western blot analysis (1 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects human Hrk fused with green fluorescent protein in crude extracts of E. coli transfected with Hrk-GFP. |
Other Names | BID3 |
Target/Specificity | Hrk |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-human Hrk polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Hrk Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HRK |
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Synonyms | BID3 |
Function | Promotes apoptosis. |
Cellular Location | Membrane; Single-pass membrane protein. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Bcl-2 family of proteins interact to regulate programmed cell death, or apoptosis. Various homodimers and heterodimers formed by proteins in this family can either promote or inhibit apoptosis. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect on certain hematopoietic cell lines following growth factor withdrawal. Additional apoptotic inhibitors in this family include Bcl-x, Bcl-w, Mcl-1, Bag-1 and A1. Pro-apoptotic members of this family include Bax, Bad, Bak, NBK (Bik), BID and Hrk. Hrk (for harakiri), designated DP5 or neuronal death protein in mouse and rat, contains a BH3 domain with high homology to other Bcl-2 family members but lacks the conserved BH1 and BH2 domains. Physical interaction of Hrk with Bcl-2 or Bcl-xL inhibits the apoptotic activity of Hrk.
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