SETD3 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q86TU7 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67257 Da |
Gene ID | 84193 |
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Positive Control | Western blot: rat Kidney lysate |
Application & Usage | Western blot: 1:200 |
Other Names | SET domain containing 3 |
Target/Specificity | SETD3 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 200 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2 |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | SETD3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SETD3 |
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Function | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N- methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). |
Cellular Location | Cytoplasm. Nucleus Note=Localizes mainly in the cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone-lysine N- methyltransferase SETD3 has a function as methylation of Lys36 of histone H3 which represents a specific tag for epigenetic transcriptional activation. It is highly expressed in muscular tissues. SETD3 contains 1 SET domain. The function of the SETD3 protein remains unknown. There are 3 isoforms produced by alternative splicing.
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