GFAP Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P14136 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49880 Da |
Gene ID | 2670 |
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Positive Control | Rat kidney tissue lysate |
Application & Usage | The antibody can be used in Western Blot analysis (4-10 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
Other Names | Glial fibrillary acidic protein |
Target/Specificity | GFAP |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti - GFAP polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | GFAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GFAP |
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Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Cellular Location | Cytoplasm. Note=Associated with intermediate filaments |
Tissue Location | Expressed in cells lacking fibronectin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GFAP, Glial fibillary acidic protein is an intermediate filament protein. It was found in astrocytes cells as a cell specific marker in the central nervous system development. GFAP is defective in Alexander disease. But it is highly expressed in Astrogliosis which is a result of some diseases, such as AIDS, dementia and inflammatory demyelination diseases.
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