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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SODD Antibody   

SODD Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O95429
Other Accession NP_004865
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Application & Usage Western blot analysis (1-2 µg/ml). However, the optimal conditions should be determined individually. The antibody detects an approximately 60 kDa human SODD by Western blot analysis. HeLa and THP-1 cell lysate can be used as positive control.

Other Names silencer of death domains, BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains
Target/Specificity SODD
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) peptide affinity purified, rabbit anti-SODD polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSODD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAG4
Synonyms SODD
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. EMBL; AF095194; AAD16123.2; -; mRNA EMBL; AF111116; AAD05226.1; -; mRNA EMBL; AK304072; BAG64979.1; -; mRNA EMBL; AC084024; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC038505; AAH38505.2; -; mRNA CCDS; CCDS56533.1; -. [O95429-2] CCDS; CCDS6104.1; -. [O95429-1] RefSeq; NP_001191807.1; NM_001204878.1. [O95429-2] RefSeq; NP_004865.1; NM_004874.3. [O95429-1] UniGene; Hs.194726; - PDB; 1M62; NMR; -; A=376-457 PDB; 1M7K; NMR; -; A=358-456 PDBsum; 1M62; - PDBsum; 1M7K; - ProteinModelPortal; O95429; - SMR; O95429; - BioGrid; 114906; 89 IntAct; O95429; 137 MINT; O95429; - STRING; 9606.ENSP00000287322; - iPTMnet; O95429; - PhosphoSitePlus; O95429; - BioMuta; BAG4; - EPD; O95429; - MaxQB; O95429; - PaxDb; O95429; - PeptideAtlas; O95429; - PRIDE; O95429; - ProteomicsDB; 50875; - ProteomicsDB; 50876; -. [O95429-2] DNASU; 9530; - Ensembl; ENST00000287322; ENSP00000287322; ENSG00000156735. [O95429-1] Ensembl; ENST00000432471; ENSP00000393298; ENSG00000156735. [O95429-2] GeneID; 9530; - KEGG; hsa:9530; - UCSC; uc003xky.3; human. [O95429-1] CTD; 9530; - DisGeNET; 9530; - EuPathDB; HostDB:ENSG00000156735.10; - GeneCards; BAG4; - HGNC; HGNC:940; BAG4 HPA; CAB013716; - HPA; HPA018951; - MIM; 603884; gene neXtProt; NX_O95429; - OpenTargets; ENSG00000156735; - PharmGKB; PA25240; - eggNOG; KOG4361; Eukaryota eggNOG; ENOG4111WNH; LUCA GeneTree; ENSGT00530000063256; - HOGENOM; HOG000290673; - HOVERGEN; HBG004809; - InParanoid; O95429; - KO; K09558; - OMA; PAETTWP; - OrthoDB; EOG091G08LY; - PhylomeDB; O95429; - TreeFam; TF102013; - Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response Reactome; R-HSA-5655302; Signaling by FGFR1 in disease Reactome; R-HSA-75893; TNF signaling Reactome; R-HSA-8853336; Signaling by plasma membrane FGFR1 fusions SIGNOR; O95429; - ChiTaRS; BAG4; human EvolutionaryTrace; O95429; - GeneWiki; BAG4; - GenomeRNAi; 9530; - PRO; PR:O95429; - Proteomes; UP000005640; Chromosome 8 Bgee; ENSG00000156735; - CleanEx; HS_BAG4; - ExpressionAtlas; O95429; baseline and differential Genevisible; O95429; HS GO; GO:0005829; C:cytosol; IDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; TAS:Reactome GO; GO:0051087; F:chaperone binding; IEA:InterPro GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl GO; GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc GO; GO:2001145; P:negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IEA:Ensembl GO; GO:1903215; P:negative regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl GO; GO:0010763; P:positive regulation of fibroblast migration; IEA:Ensembl GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl GO; GO:0006457; P:protein folding; TAS:ProtInc GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl GO; GO:1900034; P:regulation of cellular response to heat; TAS:Reactome GO; GO:0097178; P:ruffle assembly; IEA:Ensembl GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome Gene3D; 1.20.58.120; -; 1 InterPro; IPR036533; BAG_dom_sf InterPro; IPR003103; BAG_domain Pfam; PF02179; BAG; 1 SMART; SM00264; BAG; 1 SUPFAM; SSF63491; SSF63491; 1 PROSITE; PS51035; BAG; 1 1: Evidence at protein level; 3D-structure; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Methylation; Phosphoprotein; Reference proteome CHAIN 1 457 BAG family molecular chaperone regulator 4 /FTId=PRO_0000088870 DOMAIN 379 456 BAG. {ECO:0000255|PROSITE- ProRule:PRU00369} MOD_RES 7 7 Phosphoserine MOD_RES 40 40 Omega-N-methylarginine MOD_RES 53 53 Omega-N-methylarginine MOD_RES 108 108 Omega-N-methylarginine MOD_RES 185 185 Omega-N-methylarginine VAR_SEQ 90 125 Missing (in isoform 2) /FTId=VSP_042741 MUTAGEN 414 414 E->A: Reduces interaction with HSP70 MUTAGEN 424 424 D->A: Abolishes interaction with HSP70 MUTAGEN 438 439 RK->AA: Reduces interaction with HSP70 MUTAGEN 446 446 Q->A: Abolishes interaction with HSP70 HELIX 380 399 {ECO:0000244|PDB:1M62} HELIX 407 423 {ECO:0000244|PDB:1M62} HELIX 432 456 {ECO:0000244|PDB:1M62} SEQUENCE 457 AA; 49594 MW; B89D59E8118684A3 CRC64; MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS NYWNSTARSR APYPSTYPVR PELQGQSLNS YTNGAYGPTY PPGPGANTAS YSGAYYAPGY TQTSYSTEVP STYRSSGNSP TPVSRWIYPQ QDCQTEAPPL RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE DAWASPGAYG MGGRYPWPSS APSAPPGNLY MTESTSPWPS SGSPQSPPSP PVQQPKDSSY PYSQSDQSMN RHNFPCSVHQ YESSGTVNND DSDLLDSQVQ YSAEPQLYGN ATSDHPNNQD QSSSLPEECV PSDESTPPSI KKIIHVLEKV QYLEQEVEEF VGKKTDKAYW LLEEMLTKEL LELDSVETGG QDSVRQARKE AVCKIQAILE KLEKKGL
Research Areas
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Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family thro µgh their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules thro µgh the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domain. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

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$ 265.00
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