|Calculated MW||37231 Da|
|Positive Control||Jurkat cell lysate|
|Application & Usage||Western blotting (3-6 mg/ml). However, the optimal concentrations should be determined individually.|
|Other Names||Cdw150 antibody, Estm51 antibody, Ipo 3 antibody, IPO-3 antibody, Ipo3 antibody, MGC151472 antibody, MGC151476 antibody, RGD1560634 antibody, Signaling lymphocytic activation molecule antibody, Signaling lymphocytic activation molecule family member 1 antibody, Signaling lymphocytic activation molecule precursor antibody, Slaf1 antibody|
|Formulation||200 mg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||SLAM/CD150 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells|
|Tissue Location||Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation|
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Provided below are standard protocols that you may find useful for product applications.
Signaling lymphocytic activation molecule (SLAM/CD150) is expressed at hematopoietic tissue, such as memory T-cells, as well as at immature thymocytes. It has high-affinity self-ligand ability and plays an important role in interaction of T and B cells.
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