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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Caspase-8 Antibody (Clone C502S)   

Caspase-8 Antibody (Clone C502S)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O89110
Other Accession BC006737
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names C502S
Calculated MW 55357 Da
Additional Information
Gene ID 12370
Application & Usage Western blotting (0.5-4 µg/ml) and immunoprecipitation (10 µg/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8.
Other Names CASP8 , MGC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC
Target/Specificity Caspase-8 (Active)
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (200 µg/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-8 Antibody (Clone C502S) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp8
Function Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
Cellular Location Cytoplasm.
Tissue Location Expressed in a wide variety of tissues. Highest expression in spleen, thymus, lung, liver and kidney Lower expression in heart, brain, testis and skeletal muscle
Research Areas
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Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.

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$ 365.00
Cat# ABV10203
(40 western blots)
Availability: 5-7days
Bulk Size
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