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TCTN2 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q3B7D3
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 77301 Da
Additional Information
Gene ID 689779
Positive Control Jurkat cell lysate
Application & Usage Western Blot analysis (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.
Other Names Tectonic-2
Target/Specificity TCTN2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- TCTN2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTCTN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tctn2
Synonyms Tect2
Function Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme
Citations (0)

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TCTN2 is a member of the Tectonic protein family. Tectonic proteins are transmembrane proteins that regulate the Hedgehog (Hh)-signaling pathway. Defects in TCTN2 can lead to Meckel syndrome type 8. This disorder is characterized by a combination of renal cysts and variable associated features which includes developmental anomalies of the central nervous system, hepatic ductal dysplasia and cysts, and polydactyly.

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$ 245.00
Cat# ABV10207
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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