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TCTN2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q3B7D3 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77301 Da |
| Gene ID | 689779 |
|---|---|
| Positive Control | Jurkat cell lysate |
| Application & Usage | Western Blot analysis (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
| Other Names | Tectonic-2 |
| Target/Specificity | TCTN2 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti- TCTN2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | TCTN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tctn2 |
|---|---|
| Synonyms | Tect2 |
| Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TCTN2 is a member of the Tectonic protein family. Tectonic proteins are transmembrane proteins that regulate the Hedgehog (Hh)-signaling pathway. Defects in TCTN2 can lead to Meckel syndrome type 8. This disorder is characterized by a combination of renal cysts and variable associated features which includes developmental anomalies of the central nervous system, hepatic ductal dysplasia and cysts, and polydactyly.
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