|Reactivity||Human, Mouse, Rat|
|Calculated MW||34448 Da|
|Positive Control||Jurkat cell lysate, mouse 3T3 cell lysate, and rat kidney tissue lysate|
|Application & Usage||The antibody can be used for Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately.|
|Other Names||Hydroxyacyl-coenzyme A dehydrogenase|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-HADH/HCDH polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||HADH/HCDH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Had, Hadhsc, Schad|
|Function||Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
L-3-hydroxyacyl-CoA dehydrogenase (HADH/HCDH) is a mitochondrial matrix protein expressed in pancreas, liver, heart, kidney and skeletal muscle. L-3-hydroxyacyl-CoA dehydrogenase catalyzes the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene can lead to HADH (3-α-hydroxyacyl-CoA dehydrogenase) deficiency and familial hyperinsulinemic hypoglycemia 4 (HHF4).
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