HADH/HCDH Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9WVK7 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 34448 Da |
Gene ID | 113965 |
---|---|
Positive Control | Jurkat cell lysate, mouse 3T3 cell lysate, and rat kidney tissue lysate |
Application & Usage | The antibody can be used for Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately. |
Other Names | Hydroxyacyl-coenzyme A dehydrogenase |
Target/Specificity | HADH/HCDH |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-HADH/HCDH polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | HADH/HCDH Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Hadh |
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Synonyms | Had, Hadhsc, Schad |
Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P00348} |
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Provided below are standard protocols that you may find useful for product applications.
Background
L-3-hydroxyacyl-CoA dehydrogenase (HADH/HCDH) is a mitochondrial matrix protein expressed in pancreas, liver, heart, kidney and skeletal muscle. L-3-hydroxyacyl-CoA dehydrogenase catalyzes the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene can lead to HADH (3-α-hydroxyacyl-CoA dehydrogenase) deficiency and familial hyperinsulinemic hypoglycemia 4 (HHF4).
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