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JMJD1A Antibody

Rabbit Polyclonal Antibody

  • WB - JMJD1A Antibody ABV10215
    Western blot analysis of JMJD1A in mouse 3T3 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y4C1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 147341 Da
Additional Information
Gene ID 55818
Positive Control Mouse 3T3 cell lysate
Application & Usage The antibody can be used for Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately.
Other Names Lysine-specific demethylase 3A
Target/Specificity JMJD1A
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-JMJD1A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsJMJD1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM3A
Synonyms JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA
Function Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Cellular Location Cytoplasm. Nucleus. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
Citations (0)

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JMJD1A (Jumonji domain containing 1A), belongs to the JHDM2 histone demethylase family. Histone demethylase specifically demethylates 'Lys-9' of histone H3, thus play a central role in histone code. JMJD1A is involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 that are required for proper packaging and condensation of sperm chromatin.

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$ 245.00
Cat# ABV10215
(40 western blots)
Availability: 5-7days
Bulk Size
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