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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS3 Antibody   

RGS3 Antibody

Rabbit Polyclonal Antibody

  • WB - RGS3 Antibody ABV10220
    Western blot analysis of RGS3 in transfected HEK293 cells (right lane). The left lane is mock control.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49796
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 132336 Da
Additional Information
Gene ID 5998
Application & Usage Western blot analysis (1 µg/ml) and immunoprecipitation. However, the optimal conditions should be determined individually.
Other Names RGS3, 602189, P49796, C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ-RGS3, RGP3
Target/Specificity RGS3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) protein A-purified rabbit anti-RGS3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsRGS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS3
Function Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
Cellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear
Research Areas
Citations (0)

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RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed in many tissues and cells. The protein contains an RGS domain near the carboxy terminus that serves as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Giα and Gαq. A truncated RGS3 (RGS3T), with its N-terminal 313 residues removed, has been shown to negatively regulate acenylyl cyclase and PLC. RGS3T may be localized in the nucleus and RGS3 is found in cytoplasm. Translocation to membrane is important for the RGS proteins to interact with heterotrimeric G proteins.

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$ 265.00
Cat# ABV10220
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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