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Profilin-1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - Profilin-1 Antibody ABV10232
    Western blot analysis of Profilin 1 using lysate From Jurkat cells (Lane 1), 3T3 cells (Lane 2) and rat kidney tissue lysate (Lane 3).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P62963
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 14957 Da
Additional Information
Gene ID 64303
Positive Control Jurkat cell lysate, 3T3 cell lysate, rat kidney tissue lysate
Application & Usage The antibody can be used in Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. Expected band is ~15 kDa.
Other Names Profilin I, Pfn1, Epididymis tissue protein Li 184a
Target/Specificity Profilin-1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-Profilin-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsProfilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pfn1
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity).
Cellular Location Cytoplasm, cytoskeleton.
Research Areas
Citations (0)

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Background

Profilin is a protein which maintains and shapes cytoskeleton by binding to actin. Profilin 1 has function in breast cancer cell motility, radial migration and glial cell adhesion.

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$ 245.00
Cat# ABV10232
Size:
Quantity:
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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