|Calculated MW||64666 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects the ~63 kDa human CIKS/Act1. Human placenta tissue lysate can be used as a positive control.|
|Other Names||CIKS, ACT1, ACT-1, TRAF3IP2, C6orf4, C6orf5, C6orf6, RAF3-interacting protein 2, Nuclear factor NF-kappa-B activator 1; ACT1; Adaptor protein CIKS; Adapter protein CIKS|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-CIKS/Act1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CIKS/Act1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C6orf2, C6orf4, C6orf5, C6orf6|
|Function||Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
CIKS (for connection to IKK and SAPK/JNK), also called Act1 (for NF-kB activator 1), is a novel protein that associates with and activates IKK (IkB kinase). CIKS/Act1 also activates ATF (activating transcription factor) and AP-1 (activator protein 1) thro µgh Jun kinase (JNK). CIKS/Act1 is ubiquitously expressed in human tissues.
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