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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Caspase-4 Antibody (Clone D44)   

Caspase-4 Antibody (Clone D44)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49662
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names D44
Calculated MW 43262 Da
Additional Information
Gene ID 837
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. 293 cell lysate can be used as a positive control. Detects the 43 kDa human caspase-4
Other Names CASP-4, ICH-2 protease, TX protease, ICH2
Target/Specificity Caspase-4
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) immunoaffinity purified mouse IgG in PBS containing 0.5% BSA, 1.5 mM sodium azide and 30% glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-4 Antibody (Clone D44) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP4
Synonyms ICH2
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.
Cellular Location Endoplasmic reticulum membrane. Mitochondrion
Tissue Location Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain
Research Areas
Citations (0)

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The caspase family of cysteine proteases play a key role in apoptosis. Like other caspases in the family, caspase-4 is also synthesized as inactive pro-enzyme that is processed in cells by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-4 consists of large and small subunits which associate to form an active enzyme. Caspase-4 has been implicated involving in Fas-mediated apoptosis.

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$ 295.00
Cat# ABV10240
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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