|Reactivity||Human, Mouse, Rat|
|Calculated MW||27089 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal dilution conditions should be determined individually. The affinity-purified rabbit antibody recognizes ~32 kDa ILP-2 in samples from human, mouse and rat origins.|
|Other Names||BIRC8 , BIRC 8, BIRC-8, ILP2, hILP2, ILP-2, hILP 2 , IAP like protein 2|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-ILP-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ILP-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects against apoptosis mediated by BAX.|
|Tissue Location||Testis specific in normal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
ILP-2 (for IAP-like protein-2) is a novel member of in the IAP (Inhibitor of Apoptosis) protein family. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibit apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9.
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