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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   p53DINP1 Antibody   

p53DINP1 Antibody

Rabbit Polyclonal Antibody

  • WB - p53DINP1 Antibody ABV10250
    Western blot analysis of p53DINP1 expression in rat kidney tissue lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96A56
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27366 Da
Additional Information
Gene ID 94241
Application & Usage Western blotting (0.5-4 µg/ml) and Immunohistochemistry (5-10 µg/ml). However, the optimal dilution conditions should be determined individually. Human Lung tissue lysate can be used as a positive control. The antibody detects the 27 kDa p53DINP1-α in human, mouse, and rat samples. A lower band (~18 kDa) which represents the p53DINP1-β was also detected in certain tissue and cells.
Other Names TP53DINP1 Teap, TP53DINP1A, p53DINP1, P53DINP1, TP53DINP1, SIP , FLJ22139, DKFZp434M1317, TP53INP1B
Target/Specificity p53DINP1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg(0.5 mg/ml) affinity purified rabbit anti-p53DINP1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
Precautionsp53DINP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53INP1
Synonyms P53DINP1, SIP
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Cellular Location Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation
Tissue Location Ubiquitously expressed.
Research Areas
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p53DINP1 (p53-dependent damage-inducible nuclear protein 1) encodes two proteins termed p53DINP1-α (27 kDa) and p53DINP1-β (18 kDa). p53DINP1 may regulate p53-dependent apoptosis thro µgh phosphorylation at Ser46 and induction of p53AIP1. p53DINP1 is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress.

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$ 255.00
Cat# ABV10250
(40 western blots)
Availability: 5-7days
Bulk Size
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