|Reactivity||Human, Mouse, Rat|
|Calculated MW||26538 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects BI-1 in samples from mouse, rat and human origins. |
|Other Names||Bax inhibitor-1, BI-1, Bax, Bax inhibitor|
|Formulation||100 µg (0.2 mg/ml) affinity purified rabbit anti-BI-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BI-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Highly abundant in testis.|
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Provided below are standard protocols that you may find useful for product applications.
BI-1 (Bax inhibitor-1), also designated TEGT for testis enhanced gene transcript, was identified as an additional inhibitor of apoptosis. BI-1 interacts with Bcl-2 and Bcl-xL, but not with Bax or Bak, to inhibit Bax induced apoptosis.
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