|Calculated MW||35015 Da|
|Positive Control||Jurkat cell lysate|
|Application & Usage||Western blotting (0.5-4 µg/ml).|
|Other Names||Tissue factor pathway inhibitor, TFPI, Extrinsic pathway inhibitor, EPI, Lipoprotein-associated coagulation inhibitor, LACI|
|Formulation||100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-TFPI polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TFPI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.|
|Cellular Location||Isoform Alpha: Secreted.|
|Tissue Location||Mostly in endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
TFPI is also known as lipoproteinassociated coagulation inhibitor (LACI). TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates the formation of factor VIIa-TF complex, which proteolytically activates additional proteases and this leads to the formation of a fibrin clot. The encoded protein is glycosylated and primarily found in the vascular endothelium and plasma.
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