|Reactivity||Human, Mouse, Rat|
|Calculated MW||54088 Da|
|Application & Usage||Western blotting at 1-2 µg/ml. However, the optimal concentrations should be determined individually. The anti-CaMKII antibody recognizes the 50 kDa of CamonkeyII in samples from human, mouse, and rat origins.|
|Other Names||CAMK2A , CAMKA , KIAA0968, EC 184.108.40.206|
|Formulation||100 µg (0.5 mg/ml) purified rabbit polyclonal anti-CaMKII antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CaMKII Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse Note=Postsynaptic lipid rafts.|
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Provided below are standard protocols that you may find useful for product applications.
CaMKII is a member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaMKII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaMKII further autophosphorylates itself at Thr286 to render the kinase constitutively active.
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