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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   AFX Antibody   

AFX Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P98177
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 53684 Da
Additional Information
Gene ID 4303
Application & Usage Western blotting (0.5-4 µg/ml).However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control. The antibody detects 60 kDa Fox04 from samples of human, mouse, and rat origins.
Other Names FOXO4/FAX , AFX , AFX1 , MLLT7 , AFX , FoxO4 , AFX
Target/Specificity AFX
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-AFX polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAFX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXO4
Synonyms AFX, AFX1, MLLT7
Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Cellular Location Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm Dephosphorylation triggers nuclear translocation Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm
Tissue Location Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas
Research Areas
Citations (0)

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Fox04 is a member of the Forkhead family of transcription factors which are involved in tumorigenesis and other pathological processes. Fox04 has been shown to mediate signaling via a pathway involving IGFR1, PI3K, and Akt.

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$ 245.00
Cat# ABV10294
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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