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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MLK3 Antibody   

MLK3 Antibody

Rabbit Polyclonal Antibody

  • WB - MLK3 Antibody ABV10314
    Western blot analysis of MLK3 expression with HeLa cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16584
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 92688 Da
Additional Information
Gene ID 4296
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 92 kDa MLK3 of human, mouse, and rat origins. It does not cross-react with MLK1, MLK2 and other mixed lineage kinases.

Other Names MAP3K11 , MLK3 , SPRK , MLK-3 , PTK1 , MGC17114
Target/Specificity MLK3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsMLK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP3K11 (HGNC:6850)
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent
Tissue Location Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Research Areas
Citations (0)

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MLK3 (Mixed lineage kinase 3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and two leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. MLK3 functions as a MAPKKK of the SAPK/JNK stress pathway by directly phosphorylating SEK1/MKK4 and MKK7, altho µgh it is controversial whether MLK3 is involved in p38 stress pathway activation. MLK3 also functions as an IkB kinase and mediates the activation of the transcriptional factor NF-kB stimulated by CD3/CD28, s µggesting a role for MLK3 in immune and inflammatory responses.

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$ 265.00
Cat# ABV10314
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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