|Calculated MW||284525 Da|
|Application & Usage||Western blotting (1 - 4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects JMJ1DC of human origin. Reactivity to other species has not been tested.|
|Other Names||JmjC domain-containing histone demethylation protein 2C, jumonji domain-containing protein 1C, thyroid receptor-interacting protein 8, TRIP-8, TRIP8, JHDM2C, FLJ14374, RP11-10C13.2, DKFZp761F0118, KIAA1380|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti- JMJDC1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||JMJD1C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||JHDM2C, KIAA1380, TRIP8|
|Function||Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).|
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JMJD1C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism.
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