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TLR3 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q99MB1 |
| Other Accession | EDL35548 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103671 Da |
| Gene ID | 142980 |
|---|---|
| Other Names | TLR-3 , CD283, Toll-like receptor 3 |
| Target/Specificity | TLR3 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | TLR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tlr3 {ECO:0000312|MGI:MGI:2156367} |
|---|---|
| Function | Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane {ECO:0000250|UniProtKB:O15455} Early endosome {ECO:0000250|UniProtKB:O15455} |
| Tissue Location | Highly expressed in lung. After intraperitoneal injection of lipopolysaccharide, highly expressed in brain, heart, kidney, liver, lung and spleen |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
To date, at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA, induces the activation of NF-kB, thro µgh MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). Similar to several other members of the TLR family, TLR3 has been reported to be expressed at a very low level on the surface of human fibroblast cell lines.
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