|Application ||WB, IHC|
|Clone Names||WR 23/2/3/3|
|Calculated MW||11006 Da|
|Application & Usage||Western blotting (1-4 µg/ml) and Immunohistochemistry. However, the optimal conditions should be determined individually. Recognizes human cystatin A. Does not cross-react with cystatin B.|
|Other Names||Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA|
|Formulation||100 µg (1 mg/ml) affinity purified mouse anti-Cystatin A monoclonal antibody (mouse IgG1) in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Cystatin A Antibody (Clone WR 23/2/3/3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.|
|Tissue Location||Expressed in the skin throughout the epidermis.|
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Provided below are standard protocols that you may find useful for product applications.
Cystatin A (acid cysteine proteinase inhibitor, ACPI) is a natural inhibitor of cysteine proteinases and is located mainly in the keratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epidermis. Human cystatin A consists of 98 amino acid residues and belongs to cystatin subfamily I (stefins). Among the target enzymes inhibited by cystatin A are cathepsins B, C, H, L, and S, papain and actinidin. Cystatin A has also been detected in infiltrative breast carcinoma.
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