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Cystatin A Antibody (Clone WR 23/2/3/3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P01040 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG |
| Clone Names | WR 23/2/3/3 |
| Calculated MW | 11006 Da |
| Gene ID | 1475 |
|---|---|
| Application & Usage | Western blotting (1-4 µg/ml) and Immunohistochemistry. However, the optimal conditions should be determined individually. Recognizes human cystatin A. Does not cross-react with cystatin B. |
| Other Names | Cystatin-A, Cystatin-AS, Stefin-A, Cystatin-A, N-terminally processed, CSTA, STF1, STFA |
| Target/Specificity | Cystatin A |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (1 mg/ml) affinity purified mouse anti-Cystatin A monoclonal antibody (mouse IgG1) in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Cystatin A Antibody (Clone WR 23/2/3/3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSTA |
|---|---|
| Synonyms | STF1, STFA |
| Function | This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in the skin throughout the epidermis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cystatin A (acid cysteine proteinase inhibitor, ACPI) is a natural inhibitor of cysteine proteinases and is located mainly in the keratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epidermis. Human cystatin A consists of 98 amino acid residues and belongs to cystatin subfamily I (stefins). Among the target enzymes inhibited by cystatin A are cathepsins B, C, H, L, and S, papain and actinidin. Cystatin A has also been detected in infiltrative breast carcinoma.
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