|Calculated MW||11715 Da|
|Application & Usage||Western blotting at 1:1000 dilutions. However, the optimal concentrations should be determined individually. The antibody recognizes human EG-VEGF. Reactivity to other species has not been tested.|
|Other Names||PK1 , PRK1 , Prokineticin 1 , EG-VEGF , Anti-EG-VEGF|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||EG-VEGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.|
|Tissue Location||Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Human EG-VEGF (Endocrine-gland-derived vascular endothelial growth factor) is a 9.6 kDa protein consisting of 86 amino acid residues. Human EG-VEGF induces proliferation, migration and fenestration in capillary endothelial cells derived from endocrine glands.
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