|Application ||WB, IHC, IF, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||16938 Da|
|Positive Control||IHC: Tonsil tissue|
|Application & Usage||Western blotting (1:100-500), immunoprecipitation (1:50-200), Immunohistochemistry (1:100) and immunofluorescence (1:20-100). However, the optimal concentrations should be determined individually. The antibody recognizes Fis1 of human, mouse, and rat origins.|
|Other Names||hFis1 , TTC11 , H_NH0132A01.6 , CGI-135|
|Formulation||100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 20% glycerol, 0.2% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Fis1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.|
|Cellular Location||Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
hFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been s µggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.