|Reactivity||Human, Mouse, Rat|
|Calculated MW||16938 Da|
|Application & Usage||Western blotting (1-4 µg/ml). Per research’s feedback, the antibody can also be used in immunofluorescence. However, the optimal concentrations should be determined individually. The antibody recognizes Fis1 of human, mouse, and rat origins.|
|Other Names||hFis1 , TTC11 , H_NH0132A01.6 , CGI-135|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Fis1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.|
|Cellular Location||Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
hFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been s µggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
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