Mek1/2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q02750.2 |
Other Accession | NP_002746.1 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Application & Usage | Western blotting (1:500-1000). However, the optimal concentrations should be determined individually. The antibody recognizes 45 kDa Mek1/2 of human, mouse, and rat origins. |
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Other Names | MAPK , Erk, Dual specificity mitogen-activated protein kinase kinase 1/2; MAP kinase kinase 1/2; MAPKK 1/2; ERK activator kinase 1/2; MAPK/ERK kinase 1/2; MEK 1/2 |
Target/Specificity | Mek 1/2 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Mek1/2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAP kinase kinase 1 (Mek1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Mek1 and Mek2 are involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek1 and Mek2 are activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.
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