ACAA1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q921H8 |
Other Accession | AAH12400.1 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43953 Da |
Gene ID | 113868 |
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Positive Control | Jurkat cell lysate and rat kidney tissue lysate |
Application & Usage | Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
Other Names | Acetyl-CoA acyltransferase A, Beta-ketothiolase A, |
Target/Specificity | ACAA1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-ACAA1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | ACAA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Acaa1a {ECO:0000312|MGI:MGI:2148491} |
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Synonyms | Acaa1 |
Function | Responsible for the thiolytic cleavage of straight chain 3- keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3- oxoacyl-CoAs (By similarity). |
Cellular Location | Peroxisome {ECO:0000250|UniProtKB:P09110}. Note=Transported into peroxisomes following association with PEX7 {ECO:0000250|UniProtKB:P09110} |
Tissue Location | Mainly expressed in liver and intestine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACAA1 (acetylCoenzyme A acyltransferase 1), catalyzes the conversion of acyl-CoA and acetyl-CoA to 3-oxoacyl-CoA in the fatty acid oxidation pathway. Deficiency of this enzyme can lead to pseudo-Zellweger syndrome.
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