|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||66653 Da|
|Application & Usage||Western blotting (1-4 µg/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal concentrations should be determined individually. The antibody recognizes the 62 kDa MMP-17 of human, mouse, and rat origins. Reactivity to other species has not been tested.|
|Other Names||MMP17 , MMP-17 , MT4MMP , MT4-MMP , Matrix metalloproteinases, Matrix metalloproteinase-17; MMP-17; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP|
|Formulation||100 µg (0.2 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||MMP-17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.|
|Cellular Location||Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types|
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Provided below are standard protocols that you may find useful for product applications.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. MMP-17 (also designated MT-MMP4 or MT4-MMP) is a glycosylphosphatidylinositol (GPI)-anchored proteinase and is mainly expressed in the brain, leukocytes, colon, ovary and testis.
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