|Reactivity||Human, Mouse, Rat|
|Calculated MW||44765 Da|
|Positive Control||Jurkat cell lysate and rat kidney tissue lysate|
|Application & Usage||Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.|
|Other Names||Short-chain specific acyl-CoA dehydrogenase, Butyryl-CoA dehydrogenase|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-ACADS polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ACADS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Introduces a double bond at position 2 in saturated acyl-CoAs of short chain length, i.e. less than 6 carbon atoms.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
ACADS (acyl-Coenzyme A dehydrogenase), is a homotetrameric mitochondrial flavoprotein that belongs to the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutation of this gene causes SCAD deficiency an acute acidosis and muscle weakness in infants and lipid-storage myopathy in adults.
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