ACADS Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P15651 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44765 Da |
Gene ID | 64304 |
---|---|
Positive Control | Jurkat cell lysate and rat kidney tissue lysate |
Application & Usage | Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
Other Names | Short-chain specific acyl-CoA dehydrogenase, Butyryl-CoA dehydrogenase |
Target/Specificity | ACADS |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-ACADS polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | ACADS Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Acads |
---|---|
Function | Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl- CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:3968063). |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:Q3ZBF6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACADS (acyl-Coenzyme A dehydrogenase), is a homotetrameric mitochondrial flavoprotein that belongs to the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutation of this gene causes SCAD deficiency an acute acidosis and muscle weakness in infants and lipid-storage myopathy in adults.
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