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Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17)

Mouse Monoclonal Antibody

     
  • WB - Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17) ABV10399-100
    Western blot analysis of recombinant PI9: Lane 1: 2 μg;Lane 2: 5 μg; Lane 3: 10 μg
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P50453
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names PI9-17
Calculated MW 42404 Da
Additional Information
Gene ID 5272
Application & Usage Western blotting (2-4 µg/ml) and Immunohistochemistry (20 µg/ml). It recognizes 42 kDa native human PI-9 and the 63 kDa PI-9 complexed to granzyme B. Reactivity to other species has not been tested.
Other Names CAP3 CAP3 Cytoplasmic antiase3 PI9 Protease inhibitor9 ovalbumin type Serpin B9 Serine or Cysteine ase Inhibitor
Target/Specificity PI9
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) mouse monoclonal antibody from culture supernatant diluted in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsProteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINB9
Synonyms PI9
Function Granzyme B inhibitor.
Cellular Location Cytoplasm.
Research Areas
Citations (0)
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Background

Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling.

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Discontinued
Cat# ABV10399-100
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