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TLR8 (TAntibody (Clone 44B05)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NR97
Other Accession NP_619542
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names 44B05
Calculated MW 119828 Da
Additional Information
Gene ID 51311
Application & Usage Western blotting (1:200-1000 dilutions) and FACS analysis. Ramos cell lysate can be used as a positive control and a 120 kDa band is detected in Western blotting. For FACS analysis, we recommend 1-4 ml per million cells. However, the optimal conditions should be determined individually.
Other Names LR8 , Anti-TLR8 , CD288 , CD 288 , MGC119599 , # MGC119600
Target/Specificity TLR8
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl (1 mg/ml) Protein G purified mouse anti-TLR8 monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTLR8 (TAntibody (Clone 44B05) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR8
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells
Research Areas
Citations (0)

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The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1 contains an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and s µggests that these receptors are involved in mediating inflammatory responses. TLR6 is highly homologous to TLR1, and like other members of TLR family, it induces NFkB signaling upon activation. TLR8 gene contains three exons, two of which have coding function. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.

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$ 345.00
Cat# ABV10409
(40 western blots)
Availability: 5-7days
Bulk Size
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