|Calculated MW||45265 Da|
|Application & Usage||Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes mouse TROY. Reactivity to other species has not been tested.|
|Other Names||TAJ alpha , TAJ , TNFRSF 19 , TRADE , Tnfrsf19 , AL023044 , AW123854 , TRADE , Tnfrsf20 , Troy|
|Formulation||100 µg (0.5 mg/ml) rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TROY/TAJ Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 4: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver|
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Provided below are standard protocols that you may find useful for product applications.
TROY (also designated TAJ), a member of the TNFR superfamily, exists as several isoforms that vary in functions. Full length TROY contains a cytoplasmic tail, which recruits tumor necrosis factor receptor-associated factor (TRAF) 2. The interaction between TROY and TRAF2 promotes cell survival thro µgh the NFκB signaling pathway. One truncated version of TROY, designated TNFRSF19, contains a shortened cytoplasmic tail, which prevents TNFRSF19 from activating the NFκB signal transduction pathway.
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