TROY/TAJ Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9JLL3 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45265 Da |
Gene ID | 29820 |
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Application & Usage | Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes mouse TROY. Reactivity to other species has not been tested. |
Other Names | TAJ alpha , TAJ , TNFRSF 19 , TRADE , Tnfrsf19 , AL023044 , AW123854 , TRADE , Tnfrsf20 , Troy |
Target/Specificity | TROY/TAJ |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TROY/TAJ Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tnfrsf19 |
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Synonyms | Taj, Troy |
Function | Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors. |
Cellular Location | [Isoform 1]: Cell membrane; Single- pass type I membrane protein [Isoform 4]: Cell membrane; Single- pass type I membrane protein |
Tissue Location | Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebellum, but not in the skin epidermis. Isoform 3 was found in embryonic day 17.5 skin but not in brain and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
TROY (also designated TAJ), a member of the TNFR superfamily, exists as several isoforms that vary in functions. Full length TROY contains a cytoplasmic tail, which recruits tumor necrosis factor receptor-associated factor (TRAF) 2. The interaction between TROY and TRAF2 promotes cell survival thro µgh the NFκB signaling pathway. One truncated version of TROY, designated TNFRSF19, contains a shortened cytoplasmic tail, which prevents TNFRSF19 from activating the NFκB signal transduction pathway.
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