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Wnt-6 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P22727 |
| Other Accession | NP_033552.2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39656 Da |
| Gene ID | 22420 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml), Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 40-46 kDa Wnt-6 from rat origins. Reactivity to other species has not been tested. |
| Other Names | wnt6, wnt 6, wnt-6, wingless-related MMTV integration site 6, |
| Target/Specificity | Wnt-6 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit Wnt-6 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Wnt-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Wnt6 |
|---|---|
| Synonyms | Wnt-6 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Detected in ileum, colon and stomach (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Wnt gene family members, including Wnt-1 thro µgh Wnt-10, play a key role in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue. Wnt-3 is involved in tumorigenesis and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue. Wnt-6 is involved in oncogenesis and is co-expressed with Wnt10 in colorectal cancer cell lines. The presence of cervical and breast cell carcinomas may indicate an over expression of Wnt-6.
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