|Reactivity||Human, Mouse, Rat|
|Calculated MW||39052 Da|
|Application & Usage||Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive controls. The antibody recognizes 39 kDa Wnt-4 of human, mouse and rat origins. Reactivity to other species has not been tested.|
|Other Names||OTTHUMP00000044725 , WNT-4 , WNT-4 protein , WNT4|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Wnt-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Wnt gene family members, including Wnt-1 thro µgh Wnt-10, play a key role in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-3 is also involved in tumorigenesis and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue.
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