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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VDAC/Porin Antibody   

VDAC/Porin Antibody

Rabbit Polyclonal Antibody

  • WB - VDAC/Porin Antibody ABV10440
    Western blot analysis of VDAC/Porin with 3T3 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21796
Reactivity Human, Mouse, Rat, Rabbit, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 30773 Da
Additional Information
Gene ID 7416
Positive Control Western Blot: 3T3 cell lysate. IHC: Liver tissue
Application & Usage Western blotting (0.5-4 µg/ml) and Immunohistochemistry (2.5 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~31 kDa VDAC/Porin from samples of human, mouse, rat, bovine, pig, and rabbit origins.
Other Names VDAC1, VDAC-1 , MGC111064 , hVDAC1, Porin
Target/Specificity VDAC/Porin
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-VDAC/Porin polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsVDAC/Porin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VDAC1
Synonyms VDAC
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Cellular Location Mitochondrion outer membrane. Cell membrane
Tissue Location Heart, liver and skeletal muscle.
Research Areas
Citations (0)

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The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is tho µght to form the major pores thro µgh which adenine nucleotides are transferred thro µgh the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is tho µght to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.

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$ 265.00
Cat# ABV10440
(40 western blots)
Availability: 5-7days
Bulk Size
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