PLTP Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | P55058 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54739 Da |
Gene ID | 5360 |
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Application & Usage | Western blotting (1:200-1000 dilutions) and in Immunohistochemistry (1:50 dilutions). However, the optimal concentrations should be determined individually. The antibody recognizes 55 kDa PLTP of human and mouse origins. |
Other Names | Phospholipid transfer protein , Lipid transfer protein II |
Target/Specificity | PLTP |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg affinity purified rabbit anti-PLTP polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA and 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | PLTP Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLTP |
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Function | Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:7654777, PubMed:9132017, PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307). |
Cellular Location | Secreted. Nucleus. Note=Nuclear export is XPO1/CRM1- dependent. |
Tissue Location | Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very low levels found in the heart, colon, skeletal muscle, leukocytes and brain. Expressed in the cortical neurons. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma phospholipid transfer protein (PLTP) plays a central role in regulating plasma HDL levels and distribution of HDL subpopulations. This regulation is evidenced in vivo by markedly reduced plasma HDL levels in PLTP gene knock-out mice. PLTP also facilitates free cholesterol influx into HDL.
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