|Application ||WB, IHC|
|Calculated MW||54739 Da|
|Application & Usage||Western blotting (1:200-1000 dilutions) and in Immunohistochemistry (1:50 dilutions). However, the optimal concentrations should be determined individually. The antibody recognizes 55 kDa PLTP of human and mouse origins. |
|Other Names||Phospholipid transfer protein , Lipid transfer protein II|
|Formulation||100 µg affinity purified rabbit anti-PLTP polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||PLTP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.|
|Tissue Location||Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain|
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Provided below are standard protocols that you may find useful for product applications.
Plasma phospholipid transfer protein (PLTP) plays a central role in regulating plasma HDL levels and distribution of HDL subpopulations. This regulation is evidenced in vivo by markedly reduced plasma HDL levels in PLTP gene knock-out mice. PLTP also facilitates free cholesterol influx into HDL.
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