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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   HDAC2 Antibody   

HDAC2 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92769
Other Accession EAW48255
Reactivity Human, Mouse, Rat, Hamster, Chicken, Dog
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55364 Da
Additional Information
Gene ID 3066
Application & Usage Western blotting (0.5-4 µg/ml) and immunocytochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 55 kDa Histone Deacetylase 2 in samples from human, mouse, rat, chicken, hamster, and canine origins.
Other Names HDAC-2, Histone Deacetylase 2, RPD3, YAF1
Target/Specificity HDAC2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-HDAC2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHDAC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC2
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed; lower levels in brain and lung
Research Areas
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HDAC2 is a class I mammalian histone deacetylase containing 488 amino acid residues with an apparent size of ~55 kDa by denaturing SDS-PAGE. HDAC2 has been shown to interact directly with transcription repressor complexes and the nuclear receptor corepressor N-CoR.

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$ 245.00
Cat# ABV10446
(40 western blots)
Availability: 5-7days
Bulk Size
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