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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EDEM3 Antibody   

EDEM3 Antibody

Rabbit Polyclonal Antibody

  • WB - EDEM3 Antibody ABV10459
    Western blot of 3T3 cell lysate with EDEM3 antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZQ6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 104664 Da
Additional Information
Gene ID 80267
Positive Control 3T3 cell lysate
Application & Usage Western blot: 1:200
Other Names Alpha-1, 2-mannosidase EDEM3
Target/Specificity EDEM3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH7.2
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsEDEM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDEM3
Synonyms C1orf22
Function Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
Cellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}
Research Areas
Citations (0)

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EDEM3 belongs to the glycosyl hydrolase 47 family. It is involved in endoplasmic reticulum-associated degradation (ERAD). Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 accelerates the degradation of misfolded glycoproteins in the ER. It also accelerates the glycoprotein ERAD by proteasomes and this process depends on mannose-trimming from the N-glycans. It is most likely to have some alpha 1, 2-mannosidase activity.

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$ 295.00
Cat# ABV10459
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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