|Reactivity||Human, Mouse, Rat|
|Calculated MW||240853 Da|
|Positive Control||Western blot: rat kidney lysate|
|Application & Usage||Western blot: 1:200|
|Other Names||Hexabrachion, Tenascin-C|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Tenascin (TN-C) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
The tenascin family of extracellular matrix proteins includes Tenascin-C (also designated cytotactin or Tenascin), Tenascin-R (also designated restrictin, TN-R or janusin) and Tenascin-X. Tenascin proteins function as substrate-adhesion molecules (SAMs) and are involved in regulating numerous developmental processes, such as morphogenetic cell migration and organogenesis. The tenascin family proteins arise from various splicing events in the region of coding for FNIII repeats. Tenascin-C and Tenascin-X are expressed in several tissues during embryogenesis and in adult tissues undergoing active remodeling, such as healing wounds and tumors. Tenascin-R is expressed on the surface of neurons and glial cells.
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