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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   FKBP12 Antibody   

FKBP12 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P26883
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 11923 Da
Additional Information
Gene ID 14225
Application & Usage Western blot (0.5-4 µg/ml), immunoprecipitation (2-10 µg/ml) and Immunohistochemistry (2-10 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 12 kDa FKBP12 protein in samples from human, mouse, and rat origins.
Other Names FKBP1A , FKBP1 , FKBP12
Target/Specificity FKBP 12
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFKBP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Fkbp1a
Synonyms Fkbp1
Function Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

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$ 245.00
Cat# ABV10479
(40 western blots)
Availability: 5-7days
Bulk Size
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