Syndecan-1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P18827 |
Reactivity | Human, Mouse, Rat, Hamster |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32462 Da |
Gene ID | 6382 |
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Application & Usage | Western blotting (0.5-4 µg/ml), However, the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~100 kDa Syndecan-1 from samples of human, mouse, rat, and hamster origins. Cross-reactivity to other species has not been determined. |
Other Names | SYND1 , SYND 1 , SDC1 , CD138 , CD138 , CD 138 , Syndecan1 , Syndecan 1 , SDC |
Target/Specificity | Syndecan-1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-Syndecan-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Syndecan-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SDC1 (HGNC:10658) |
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Synonyms | SDC |
Function | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). |
Cellular Location | Membrane; Single-pass type I membrane protein. Secreted Secreted, extracellular exosome Note=Shedding of the ectodomain produces a soluble form |
Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Syndecans are type I integral membrane proteoglycans that are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan-1 is a matrix receptor which binds to Collagens, Fibronectin and Thrombospondin. Syndecan-1 and Syndecan-3 interact with MK (midkine), a growth/differentiation factor involved in embryogenesis. Syndecan-2 is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan-4 functions cooperatively with integrins in the processes of cell spreading and focal adhesion assembly.
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