|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||38160 Da|
|Application & Usage||Western blotting (1:200-1000)and Immunohistochemistry (1:100-500). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody detects Math1 in samples from human, mouse, and rat origins. Other species have not been tested.|
|Other Names||ATOH1 , MATH-1 , ATH1 , Math1 , HATH1|
|Formulation||100 µl affinity purified rabbit anti-Math1 (also called ATH1) polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Math1 (ATH1/ATOH1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Math1 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. It is neural-specific and is switched on during differentiation into neuroectoderm.
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