TEM-8/ATR1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q9CZ52 |
Other Accession | AAL11999 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 62308 Da |
Gene ID | 69538 |
---|---|
Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~80-85 kDa doublet of TME8 in samples from human, mouse and rat origins. Reactivity to other species has not been tested. |
Other Names | Tumor Endothelial Marker 8 , TEM-8, TEM8 , ATR , FLJ10601 , FLJ11298 , FLJ21776 |
Target/Specificity | TEM-8 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.2mg/ml) affinity purified rabbit anti-TEM8/ATR1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TEM-8/ATR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Antxr1 |
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Synonyms | Atr, Tem8 {ECO:0000303|PubMed:11559528} |
Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2} Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2} Cell projection, filopodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2} Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia {ECO:0000250|UniProtKB:Q9H6X2} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor Endothelial Markers (TEMs, TEM 1-9) are recently identified genes, whose expression is elevated in tumor-associated endothelium. TEMs are barely detectable in normal endothelial cells. TEM8 has been shown to interact with C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium. It is tho µght that TEM8 may play a role in tumor angiogenesis.
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