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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   TEM-8/ATR1 Antibody   

TEM-8/ATR1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9CZ52
Other Accession AAL11999
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 62308 Da
Additional Information
Gene ID 69538
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~80-85 kDa doublet of TME8 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
Other Names Tumor Endothelial Marker 8 , TEM-8, TEM8 , ATR , FLJ10601 , FLJ11298 , FLJ21776
Target/Specificity TEM-8
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2mg/ml) affinity purified rabbit anti-TEM8/ATR1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTEM-8/ATR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Antxr1
Synonyms Atr, Tem8
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein Note=At the membrane of lamellipodia and at the tip of actin- enriched filopodia. Colocalizes with actin at the base of lamellipodia (By similarity).
Research Areas
Citations (0)

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Tumor Endothelial Markers (TEMs, TEM 1-9) are recently identified genes, whose expression is elevated in tumor-associated endothelium. TEMs are barely detectable in normal endothelial cells. TEM8 has been shown to interact with C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium. It is tho µght that TEM8 may play a role in tumor angiogenesis.

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$ 245.00
Cat# ABV10505
(40 western blots)
Availability: 5-7days
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