|Reactivity||Human, Mouse, Rat|
|Calculated MW||54644 Da|
|Application & Usage||Western blotting (1-4 µg/ml). The optimal concentrations should be determined individually. The antibody recognizes TAB1 in samples from human, mouse and rat origins. BaF3 cells can be used as positive controls. A ~60 kDa band should be detected. |
|Other Names||ANTI TAB1 , TAK1 , TGF beta activated kinase 1 , MGC57664 , MAP3K7IP1|
|Formulation||100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TAB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
TAB1 (TAK1 binding protein 1) is an adaptor protein that can activate TAK1 in vivo thro µgh phosphorylation of TAK1, a mitogen-activated protein kinase kinase kinase. Once activated TAK1 phosphorylates MAPK kinase MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively.
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