|Reactivity||Human, Mouse, Rat|
|Calculated MW||78123 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). The optimal concentrations should be determined individually. A ~80 kDa band and a smaller ~45 kDa cleavage fragment can be detected.|
|Other Names||DVL3 , KIAA0208 , Dishevelled-3, Dishevelled3|
|Formulation||100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Dvl3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the signal transduction pathway mediated by multiple Wnt genes.|
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Provided below are standard protocols that you may find useful for product applications.
Dvl1, Dvl2, and Dvl3 are mammalian homologs of Dsh (disheveled) proteins that are involved in Wnt signaling pathways. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated and accumulate in the nucleus. Dvls have been reported to mediate endocytosis and may also play a role in certain cancers.
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